Table 4.
Proportions of explained familial risk (and 95% confidence intervals) with epidemiological approach, using different adjustment possibilities
| Linkage disequilibrium | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| - (NSNPs=97) |
D’≥0.95 (NSNPs=90) |
D’≥0.5 (NSNPs=80) |
D’≥0.1 (NSNPs=71) |
max. 1 SNP per locus (NSNPs=59) |
||||||||
| included as separate variables | 13.8 | 2.2–23.2 | 14.3 | 3.3–23.2 | 13.8 | 3.3–22.2 | 13.2 | 3.3–21.3 | 10.2 | 1.3–18.3 | ||
| included as a GRS… | categorizeda | unweighted | 10.6 | 4.8–16.9 | 10.9 | 4.8–17.0 | 8.9 | 3.4–15.2 | 7.3 | 1.9–13.8 | 6.3 | 0.8–12.5 |
| Weightedb | 8.6 | 3.9–14.5 | 8.9 | 3.6–14.9 | 8.1 | 2.8–14.7 | 7.2 | 1.3–12.2 | 5.4 | 0.8–11.4 | ||
| continuous | unweighted | 11.6 | 6.1–18.7 | 11.0 | 5.0–18.5 | 9.3 | 3.6–16.2 | 8.3 | 2.8–15.1 | 7.2 | 1.6–14.1 | |
| weightedb | 8.9 | 4.0–14.8 | 8.9 | 3.2–15.5 | 7.7 | 2.2–13.9 | 7.4 | 2.5–13.3 | 6.4 | 1.5–12.3 | ||
Please note: 95% confidence intervals of explained familial risk was calculated using bootstrapping methods (n=1000)
Abbreviations: GRS, genetic risk score; OR, odds ratio
a
Categories defined by percentiles of distribution in controls: 0–10, 10–20, 20–40, 40–60, 60–80, 80–90, 90–100
b
Weights equal to log(OR) from discovery study