Table 22.1.

Staging of acute graft-versus-host disease

Stage	Skin	Liver	Intestine
1	Rash <25 % BSA	Total bilirubin 2.0–2.9 mg/dL	Diarrhea 0.5–1 L/day or persistent nausea/emesis with +gut biopsy
2	Rash 25–50 % BSA	Total bilirubin 3.0–5.8 mg/dL	Diarrhea 1–1.5 L/day
3	Rash >50 % BSA	Total bilirubin 5.9–14.9 mg/dL	Diarrhea >1.5 L/day
4	Generalized erythemawith bullae and/or desquamation	Total bilirubin >14.9 mg/dL	Severe abdominal pain or ileus