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. Author manuscript; available in PMC: 2021 Jan 30.
Published in final edited form as: Crit Rev Biochem Mol Biol. 2020 Jan 30;54(6):484–516. doi: 10.1080/10409238.2020.1717430

Figure 4. Schematic representation of “eicosanoid class switching” mediated by selenoproteins generated from macrophages.

Figure 4.

Supplementation of Se upregulates the expression of selenoproteins, which mediate the shift of the ARA pathway to produce more anti-inflammatory PGD2 and its downstream CyPG metabolites, while decreasing the levels of pro-inflammatory PGE2 and TXA2 via the regulation of PG synthases (mPGES-1, TXS, and H-PGDS) as well as two transcription factors, i.e. NF-ĸB and PPARγ.