Table 1.

Antiviral activity and cytotoxicity of zinc ejectors

Compound	EC50 (µM)	CC50 (µM)	Therapeutic index	References
NOBA	ND	10.6	−	Huang et al. (1998)
DIBA-1	2.3	>200	>87	Huang et al. (1998), Rice et al. (1995)
Dithiane	6.6	184	30	Huang et al. (1998)
ADA	38	>200	>5	Huang et al. (1998), Rice et al. (1997a, b)
PATE-45	6.2	>316	>51	Turpin et al. (1999)
SAMT-19	2.9	461	160	Srivastava et al. (2004)
NV038	17	>300	>17	Pannecouque et al. (2010)
WDO-217	7.9	72	9	Vercruysse et al. (2012)
[SP-4-2]-[PtCl(NH3)(quin)(9-EtGH)]	41.9	>200	>4.75	Sartori et al. (2000)

EC₅₀, 50 % effective concentration (concentration of inhibitor for 50 % inhibition of viral replication); CC₅₀, 50 % cytotoxic concentration (concentration of inhibitor that kills 50 % of cells), Therapeutic index = CC₅₀/EC₅₀. ND, not determined