Table 9.2.
Selected cellular proteins and bacterial toxins cleaved by proprotein convertases
| Precursor proteins | Proprotein convertases | Cleavage sites P7 P6 P5 P4 P3 P2 P1 ↓ P1′ P2′ | References |
|---|---|---|---|
| Growth factors and hormones | |||
| Mouse ß-nerve growth factor | Furin | RTHRSKR↓SS | Bresnahan et al. (1990) |
| Human neurotrophin-3 | Furin, PC5B | TSRRKR↓YA | Seidah et al. (1996) |
| Human insulin-like growth factor-I | PACE4 | KPAKSAR↓SVa | Duguay et al. (1995) |
| Khatib et al. (2001) | |||
| Human parathyroid hormone | Furin | KSVKKR↓SVa | Hendy et al. (1995) |
| Munzer et al. (1997) | |||
| Receptors | |||
| Human insulin receptor | PC5A | PSRKRR↓SL | Robertson et al. (1993) |
| Human αv integrin | Furin, PC7 | PQRRRR↓QL | Stawowy et al. (2005) |
| Plasma proteins | |||
| Human albumin | Furin | RGVRR↓DAa | Oda et al. (1992) |
| Mori et al. (1999) | |||
| Human blood factor X | Furin, PC5 | LERRKR↓SV | Himmelspach et al. (2000) |
| Human von Willebrand factor | Furin, PACE4, PC7 | SHRSKR↓SL | van de Ven et al. (1990) |
| Matrix metalloproteinases | |||
| Human stromelysin-3 | Furin | ARNRQKR↓FV | Pei and Weiss (1995) |
| Human MT-MMP1 | Furin, PACE4 | NVRRKR↓YA | Sato et al. (1996) |
| Other cellular proteins | |||
| Human furin prodomainb | Furin, PACE4 | AKRRTKR↓DV | Anderson et al. (1997) |
| Mouse 7B2 chaperone | Furin | QRRKRR↓SV | Paquet et al. (1994) |
| Bacterial exotoxins | |||
| Anthrax toxin protective antigen | Furin | NSRKKR↓ST | Molloy et al. (1992) |
| Diphtheria toxin | Furin | GNRVRR↓SV | Tsuneoka et al. (1993) |
| Shiga toxin | Furin, PACE4 | ASRVAR↓MA | Garred et al. (1995) |
aUnusual cleavage site for furin
bAutocatalysis