Fig. 11.10.

Model of TMPRSS2 in complex with inhibitor 21. (a) Structure of inhibitor 21 (stick model with yellow carbon atoms, nitrogen in blue, oxygen in red, chlorine in green) bound into the active site of TMPRSS2, shown with its surface in gray. The 2,4-dichloro-biphenyl-3-sulfonyl residue is directed toward the distal S3/4 pocket above Trp215 indicated by a yellow surface. (b) Polar interactions of inhibitor 21 in the active site of TMPRSS2 are shown as dashed lines in black; important TMPRSS2 residues are shown with carbon atoms in green