Table 4.6.
EC50 (in μM unit) of PMs for several RNA viruses in vitro
| Compound | EC50 (μM)a | |||||
|---|---|---|---|---|---|---|
| DFV(Vero) | FluV(MDCK) | RSV(HEp-2) | PfluV-2(HMV-2) | CDV(Vero) | HIV-1(MT-4) | |
| PM-43 | 10.7 ± 6.7 | 8.4 ± 6.5 | 1.6b | >100 | 7.5 ± 0.95 | 0.3 ± 0.12 |
| PM-47 | 10.5 ± 6.9 | 11.5 ± 0.6 | 29.0b | 67.1b | 6.0 ± 0.6 | 0.03 ± 0.01 |
| PM-518 | 36.8 ± 3.0 | 62.3 ± 26.5 | 26.5b | 53.2 ± 39.2 | >50 | 2.0 ± 0.8 |
| PM-520 | 11.7 ± 7.1 | 45.2 ± 25.8 | 0.74 ± 0.58 | 23.2 ± 2.4 | 7.4 ± 0.4 | 2.0 ± 0.5 |
| PM-523 | >61.5 | 5.6 ± 2.0 | 1.3 ± 0.46 | 2.5 ± 1.0 | 7.3 ± 1.1 | 0.3 ± 0.07 |
| PM-1001 | 0.45b | 1.75 ± 1.6 | <0.16 | 1.1 ± 0.9 | 5.7 ± 0.5 | 0.14 ± 0.17 |
| PM-1002 | 1.95 ± 1.4 | 4.6 ± 1.7 | 0.75 ± 0.05 | 0.75 ± 0.05 | 2.8 ± 1.0 | 0.03 ± 0.01 |
| Ribavirin | >100 | 5.0 ± 2.75 | 3.9 ± 3.1 | 14.0 ± 4.8 | 73.6 ± 34.5 | NDc |
aEC50 values for the virus-infected cells (indicated in parenthesis) were determined by the MTT method, but for CDV by the plaque reduction method
bAverage of two experiments
cNot determined