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. 2004;90:433–450. doi: 10.1385/1-59259-429-8:433
# of Patients With DLT at Current Dose Level Dose Escalation Decision Rule
0 out of 3 Enter next three patients at the next dose level.
1 out of 3 Enter up to three additional patients at current dose level. If none or one out of the three of the second group experiences
DLT, then enter three patients at the next dose level. As soon as two of the second group experience DLT, then the MTD has been reached at the previous (lower) level and dose escalation will stop.
2 out of 3 Enter up to three additional patients at current dose level. If none experience DLT, then enter three patients at the next dose level. As soon as any patient of the second group experiences DLT, the MTD has been reached at the previous (lower) level and dose escalation will stop.
3 out of 3 The MTD has been reached at the previous (lower) level and dose escalation will stop.