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PBAE nanoparticle co-delivery of five siRNAs reduced tumor growth in an orthotopic model of human GBM. Hemotoxylin- and eosin-stained histological slides of siRNA treated tumors (A) show reduced tumor burden versus (B) scRNA treated tumors. (C) IVIS tracking of luciferase-positive GBM tumors shows inhibited tumor growth in siRNA-treated tumors. (D) Quantification of siRNA-mediated reduction in tumor burden (n = 3 per group). Scale bar = 2 mm.
