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Schematic representation of proMMP-9 activation by an aprotinin sensitive protease during IL-1β stimulation of pulmonary artery smooth muscle cells. IL-1β treatment to the cells stimulates TGF-β and TNF-α. TGF-β stimulates expression of proMMP-9, while TNF-α activates proMMP-9 via an increase in a ~43 kDa aprotinin sensitive protease concomitant with the down regulation of aprotinin and TIMP-1 expression
