Table 2.

Population Pharmacokinetic Model Parameters

PK parameter		Point Estimates	%RSE	Bootstrap Median [95% CI]
Fixed
CL= θ1 × (WT/70)0.75 * θ9INDU
θ1 (L h−1)		34.6	9.2	34.7 [27.7, 40.9]
θ9		1.54	10.1	1.54 [1.2, 1.89]
V1= θ2 × (WT /70)1	θ2 (L)	222	18.6	9.24 [3.72, 13.32]
Q= θ3 × (WT /70)0.75	θ3 (L h−1)	8.58	18.9	9.24 [3.72, 13.32]
V2= θ4 × (WT /70)1	θ4 (L)	311	13.1	332 [150, 472]
Interindividual Variability
ω2CL (%CV)		0.37 (60.7%)	38.2	0.34 [0.07, 0.67]
ω2V1 (%CV)		1.15 (107.2%)	43.1	1.15 [0.1, 2.2]
COVCL-V1		0.63 (r=0.85)	41.3	0.55 [0.04, 1.22]
Residual Variability*
Proportional (%CV)		52%	15.4	50.6% [43.3%, 59.7%]

^*Residual Variability was additive in log scale. %CV was calculated by square root of variance x 100. INDU: CYP3A4/5 Inducer.