Table 2.
Description of custom-made profiles used in this study
| EPIMHC search selection | EPIMHC search result and profile building | ||||||
|---|---|---|---|---|---|---|---|
| Profile name | MHC molecule | PEP. binding level | PEP. source organism | T-cell activity | Length | Peptides | Method |
| Profile #1 | HLA-A*0201 | High | All | All | 9 | 178 | p.mtxb |
| Profile #2 | HLA-A*0201 | High | All | YES | 9 | 95 | p.mtxb |
| Profile #3 | HLA-A*0201 | High | Virusesa | All | 9 | 48 | p.mtxb |
| Profile #4 | HLA-A*0201 | High | Virusesa | YES | 9 | 32 | p.mtxb |
aThe viruses selected in EPIMHC were the following: Dengue virus, Epstein-Barr virus, Hepatitis B virus, Hepatitis C virus, Human immunodeficiency virus 1, Human immunodeficiency virus 1 OPT, Human immunodeficiency virus 2, Influenza A virus, Measles virus, and West Nile virus. None of the CD8 T-cell epitopes from SARS nucleoprotein are included in any of the peptide selections used for making these profiles
bPSSMs generated using position-based weights [30]