Table 1. List of critical inactive ingredients that can act as allergens.
Percentage occurrence refers to fraction of all formulations of medications (solid oral dosage forms) that contain the critical ingredient.
| Ingredient | Classification | Percentage occurrence in medications |
|---|---|---|
| Lactose | food | 44.82% |
| Corn starch | food | 36.54% |
| PEG | polymer | 36.03% |
| Povidone | polymer | 35.80% |
| Carboxymethylcellulose | other | 21.38% |
| Gelatin | food | 16.93% |
| Brilliant blue | dye | 14.47% |
| Sunset Yellow FCF | dye | 12.27% |
| Allura red | dye | 11.20% |
| Propylene glycol | other | 11.14% |
| Indigo carmine | dye | 10.63% |
| Mannitol | sugar | 7.20% |
| Sucrose | sugar | 5.21% |
| Sodium benzoate | other | 1.72% |
| Parabens | other | 1.48% |
| Aspartame | other | 1.46% |
| Erythrosine | dye | 1.03% |
| Tartrazine | dye | 0.95% |
| Saccharin | other | 0.81% |
| Poloxamer | polymer | 0.76% |
| Soybean oil | food | 0.44% |
| Benzyl alcohol | other | 0.43% |
| Vanilla | food | 0.38% |
| Castor oil | food | 0.30% |
| Cetyl alcohol | other | 0.19% |
| Sulfite | other | 0.19% |
| PEG castor oils | food | 0.13% |
| Peanut oil | food | 0.08% |
| Benzoic acid | other | 0.07% |
| Corn syrup | food | 0.05% |
| Sesame Oil | food | 0.05% |
| Starch wheat | food | 0.04% |
| Casein | food | 0.03% |
| Banana essence | food | 0.01% |
| Milk | food | 0.01% |
| Glucosamine | food | 0.00% |
| New coccine | dye | 0.00% |
| Stearyl alcohol | other | 0.00% |