Fig. 3.5.

Anti-SARS activity of intranasally delivered siRNA in macaques. The SARS coronavirus (SCV)-specific antigen was detected in alveoli deep into the lungs, including various cell types (original magnification, ×200), confirmed by the specific staining with monoclonal antibodies. a The upper arrow indicates an SCV-infected type II pneumocyte and the lower arrow indicates an infected alveolar macrophage. b Arrows indicate SCV-infected epithelium-originated type I pneumocytes. c Arrows indicate SCV-antigen-positive alveolar macrophages. d–f Arrows indicate SCV-infected cells scattered within the siRNA-treated lungs [33]