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. Author manuscript; available in PMC: 2020 Apr 3.
Published in final edited form as: Nature. 2019 Mar 27;568(7750):93–97. doi: 10.1038/s41586-019-1053-2

Figure 4. Oral sodium detection promotes satiety of sodium appetite by suppressing pre-LCPDYN neurons.

Figure 4.

a, Simultaneous optical recording of pre-LCPDYN neurons and intragastric (IG) infusion. b, The effects of gastric infusion of sodium, water, and glucose (5M) on subsequent ingestive behaviors for 10 min (n = 7 mice for NaCl, n = 6 mice for water oral, n = 8 mice for controls, water IG and glucose IG). c, Oral sodium consumption suppressed pre-LCPDYN neuron s activity (n = 4 and 7 mice for eYFP and GCaMP6s). d, However, fluorescence signals were not affected by IG infusion of NaCl, water, or air. e, Quantification of c and d. *P<0.05, **P<0.01 and ***P<0.001 by Friedman, Kruskal–Wallis test (Dunn’s multiple comparison), or two-tailed Wilcoxon test. Data presented as mean ± s.e.m.