Fig 1. Schematic representation of VP8* from P[II] genogroup with its corresponding binding glycan structures.

(a) Schematic representation of P[8] VP8* and its binding glycan structures, Le^b tetra-saccharide and LNDFH I. (b) Schematic representation of P[4] VP8* and its binding glycan structures, LNDFH I and LNFP I. (c) Schematic representation of P[6] VP8* and its binding glycan structures, LNT and LNFP I. (d) Schematic representation of P[19] VP8* and its binding glycan structures, LNT and LNFP I. The red boxes encircle Le^b glycans and the blue boxes encircle non Le^b glycans. (e) Inhibition of rotavirus Wa strain replication in HT29 cells. Left) Representative indirect immunofluorescence assay (IFA) microscopy image of P[8] RV Wa strain replication focuses in HT29 cells. Right) Quantitation of viral replication focus reductions observed in wells incubated with LNDFH1-BSA and H type 1-biotin-PAA in compared with cell culture wells with media only. Le^y-PAA is a negative ligand control.