Table 2-.

Multivariable analysis of annual 1-hour daily max SO₂ [ppb] and selected outcomes in Puerto Rican children living in San Juan Metropolitan Area

Outcome= Asthma¥
	Unadjusted OR (95% CI)	Model 1 OR (95% CI)	Model 2 OR (95% CI)
N=	638	535	535
Annual average 1-hr daily max SO2, ppb	1.65 (1.29, 2.10)**	1.43 (1.06, 1.92)*	1.42 (1.05, 1.91)*
History of parental asthma	-	4.62 (3.15, 6.79)**	4.62 (3.14, 6.79)**
Atopy	-	2.14 (1.45, 3.17)**	2.19 (1.48, 3.24)**
Distance to a major roadway, per 100m	-	-	0.96 (0.89, 1.02)
Outcome= Atopyt
	Unadjusted OR (95% CI)	Model 1 OR (95% CI)	Model 2 OR (95% CI)
N=	557	534	534
Annual average 1-hr daily max SO2, ppb	1.38 (1.07, 1.79)*	1.35 (1.02, 1.78)*	1.27 (0.96, 1.68)¶
History of parental allergic rhinitis	-	1.51 (0.95, 2.39)	1.32 (0.82, 2.11)
Asthma	-	-	2.06 (1.42, 3.00)**
Distance to major roadway, per 100m	-	-	1.07 (1.00, 1.14)*
Outcome= IgEᵩ
	Unadjusted β (95% CI)	Model 1 β (95% CI)	Model 2 β (95% CI)
N=	557	535	535
Annual average 1-hr daily max SO2, ppb	0.13 (0.04, 0.21)**	0.08 (−0.01, 0.17)¶	0.08 (−0.01, 0.17)¶
Asthma	-	0.26 (0.14, 0.37)**	0.26 (0.14, 0.38)**
Distance to major roadway, per 100m	-	-	0.013 (−0.01, 0.03)

Adjusted for age, sex, annual income ≥$15,000/year, current second-hand tobacco smoke exposure, BMI z score.

^¥Physician-diagnosed asthma and wheeze in prior year.

^tAt least one positive IgE (>0.35kU/L) to Allergies tested.

^ᵩIgE log10 transformed for analyses, results per 1 unit log10

^¶p value <0.10;

^*p value<0.05;

^**p value <0.01