Table 5.21.

Adipokines and metabolic syndrome (Source: [908])

Inhibitors	Adiponectin, nitric oxide
Stimulators	Angiotensinogen, leptin, pentraxin-1,
	resistin, serpin-E1, TNFSF1
Associated anomalies	Context
Endothelial dysfunction	↓ NO
	↑ATn2, ET1, icam1, vcam1, CCL2,
	TNFSF5, TNFRSF5, oxLDL
Insulin resistance	Obesity, hypertension, glucose intolerance,
	low HDL concentration

Proinflammatory mediators favor endothelial dysfunction and insulin resistance, whereas amounts of protective adipocyte products decline with obesity (↑ increase, ↓ decrease)