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. Author manuscript; available in PMC: 2021 Mar 1.
Published in final edited form as: Biomaterials. 2019 Dec 26;235:119728. doi: 10.1016/j.biomaterials.2019.119728

Table 4.

Characteristics of HPMA star-like polymer precursors employed for the polymer-drug conjugate synthesis

Sample Core/Pol a) Mw [kg mol−1] b) Ð No. of chains on core Teor. / real c) Dh (int.) d) [nm] ζ-potential [mV] e)
S1 Dendrimer/P1-Prg 268 1.1 16 / 13.7 20.5±0.8 −1,65±0.98
S2 Dendron/P2-TT 354 1.2 10 / 8.4 23.9±0.7 −0,25±0.97
S3 PAMAM/P2-TT 456 1.3 12 / 10.8 27.1±0.4 −1,99±1.28
S4 PAMAM/P3-TT 204 1.8 10 / 8.2 22.6±0.9 −0.3±0.2
a)

Type of dendritic core used (Dendron = bisMPA dendron, dendrimer = bisMPA dendrimer, PAMAM = PAMAM dendrimer). Pol = polymer precursor used for star-like polymer formulation

b)

Molecular weights and dispersity were determined by SEC using multi-angle light scattering and refractive index detectors.

c)

Ratio between HPMA copolymer chains and dendrimer core, theoretically calculated from feed and real calculated by dividing star-like Mw with precursor Mw.

d)

Hydrodynamic diameter was measured by DLS in 0.15M NaCl

e)

ζ-potential values were obtained from Malvern Zetasizer Nano ZSP