Fig. 22.1.

Cryptogenic organizing pneumonia in a 44-year-old woman. (a, b) Lung window images of CT scans (2.5-mm section thickness) obtained at levels of distal main bronchi (a) and inferior pulmonary veins (b), respectively, show patchy areas of consolidation, ground-glass opacity, or ground-glass opacity nodules in both lungs. Lung lesions show typically peribronchovascular or subpleural distribution. (c) Coronal reformatted image (2.0-mm section thickness) also demonstrates same pattern of lung abnormalities distributed along bronchovascular bundles. (d) Low-magnification (×40) photomicrograph of surgical lung biopsy specimen obtained from right middle lobe shows alveolar-filling process with inflammation (arrows) and fibrinous exudate (open arrows). (e) High-magnification (×100) photomicrograph discloses granulation plugs (arrows) filling alveolar spaces and alveolar ducts. Patient also has histopathologically some component of capillaritis and alveolar hemorrhage