Table 32.2.
Mycalamide A, Psymberin and its analogues cytotoxicity against different human cancer cell lines [69–71]
| IC 50 (nM) | |||||
|---|---|---|---|---|---|
| Structure | PC-3 | SK-MEL-5 | Hela | T98G | KM 12 |
| Mycalamide A | 2.5 ± 0.2 | – | – | 2.87 ± 0.07 | 0.95 ± 0.02 |
| Psymberin | 0.98 ± 0.12 | 2.29 ± 0.13 | 0.64 ± 0.14 | 1.37 ± 0.06 | 0.45 ± 0.01 |
| 4-epi-psymberin | 346.5 ± 102.8 | 762.8 ± 70 | 618.6 ± 267 | 186.7 ± 51.3 | 126.08 ± 8.6 |
| 8-epi-psymberin | 200.2 ± 27.6 | 352.0 ± 2.1 | > 1000 | 85.8 ± 48.4 | 37.1 ± 5.5 |
| Psympederin | 821.8 ± 89.1 | > 1000 | > 1000 | > 1000 | 710.9 ± 35.8 |
| c-8-epi-psympederin | 255.5 ± 11.4 | > 1000 | > 1000 | > 1000 | > 1000 |