Table 5.

Clinical outcomes among patients who met DAWN or DEFUSE-3 perfusion criteria.

	Unfavorable ASPECTS (n=23)	Favorable ASPECTS (n=137)	Unadjusted OR	95%CI	p-value	Adjusted OR*	95%CI	p-value
Any ICH within 72 hours	12 (52%)	38 (28%)	2.8	1.1-7.1	0.03	2.6	1.1-6.3	0.04
Symptomatic ICH within 72 hours†	5 (22%)	4 (3%)	9.2	2.9-29.4	<0.01	16.4	3.7-72.7	<0.01
Good functional outcome‡	3/21 (14%)	52/126 (41%)	0.2	0.04-1.6	0.14	0.2	0.04-1.6	0.14
90-day mRS	5 (IQR 4-6)	3 (IQR 1-5)	0.2#	0.1-0.5	<0.01	0.2#	0.1-0.5	<0.01

^*Odds ratios adjusted for age, baseline NIHSS, intravenous thrombolysis, TICI 2b/3 recanalization, and time to recanalization, and clustered by hospital site.

^†Symptomatic ICH indicates worsening of the NIHSS by 4 or more points within 24 hours of admission with associated intracranial hemorrhage identified on computed tomography detected within 72 hours.

^‡Good functional outcome indicates mRS of 0-2 90 days after infarct.

^#Common odds ratio for achieving a better (lower) mRS score at 90 days.

ASPECTS: Alberta Stroke Program Early CT Scale, n: number of patients, OR: odds ratio, CI: confidence interval, ICH: intracerebral hemorrhage, mRS: modified Rankin Scale, NIHSS: National Institutes of Health Stroke Scale, and TICI: thrombolysis in cerebral infarction, with a score of 2b/3 indicating >50% recanalization of the previously occluded vessel.