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. Author manuscript; available in PMC: 2020 Apr 3.
Published in final edited form as: Environ Int. 2019 Jan 9;124:10–15. doi: 10.1016/j.envint.2018.12.060

Table 3.

Mortality risk ratios (95% CI) associated with a 10 ppb increase in long-term spatio-temporal and temporal NO2 in PM2.5-adjusted health models: by region and cause of death.

Cause of death and region Spatio-temporal NO2a Temporal NO2a
All-cause
 US 1.009 (1.001, 1.016) 2.019 (1.992, 2.047)
 West 0.992 (0.979, 1.006) 2.370 (2.280, 2.464)
 Center 1.035 (1.017, 1.053) 1.655 (1.615, 1.696)
 East 0.992 (0.982, 1.002) 1.623 (1.598, 1.648)
Accidental
 US 0.917 (0.873, 0.964) 0.872 (0.795, 0.956)
 West 0.984 (0.887, 1.092) 0.844 (0.635, 1.122)
 Center 0.821 (0.742, 0.908) 0.665 (0.574, 0.771)
 East 1.014 (0.944, 1.088) 0.903 (0.811, 1.006)
Non-accidental
 US 1.011 (1.003, 1.018) 2.056 (2.029, 2.085)
 West 0.992 (0.979, 1.006) 2.417 (2.324, 2.514)
 Center 1.042 (1.024, 1.060) 1.697 (1.656, 1.740)
 East 0.992 (0.981, 1.002) 1.643 (1.618, 1.669)
All cardiovascular
 US 1.042 (1.031, 1.054) 4.034 (3.949, 4.121)
 West 1.026 (1.006, 1.048) 3.663 (3.452, 3.887)
 Center 1.171 (1.139, 1.205) 3.143 (3.022, 3.269)
 East 0.988 (0.972, 1.004) 2.647 (2.583, 2.713)
Ischemic heart disease
 US 1.058 (1.042, 1.074) 5.628 (5.468, 5.793)
 West 1.045 (1.018, 1.074) 4.908 (4.533, 5.313)
 Center 1.197 (1.197, 1.246) 4.204 (3.975, 4.445)
 East 1.007 (1.007, 1.028) 3.238 (3.134, 3.346)
Cerebrovascular disease
 US 1.046 (1.018, 1.075) 5.806 (5.508, 6.121)
 West 1.075 (1.024, 1.129) 4.059 (3.541, 4.652)
 Center 1.183 (1.108, 1.264) 3.640 (3.327, 3.982)
 East 0.994 (0.955, 1.035) 3.436 (3.223, 3.663)
Congestive heart failure
 US 1.026 (0.980, 1.075) 1.231 (1.132, 1.339)
 West 1.035 (0.941, 1.138) 2.101 (1.604, 2.751)
 Center 1.180 (1.062, 1.311) 1.455 (1.269, 1.668)
 East 0.863 (0.810, 0.919) 1.835 (1.746, 1.929)
All respiratory
 US 0.978 (0.957, 1.000) 2.619 (2.511, 2.731)
 West 0.935 (0.899, 0.973) 4.661 (4.160, 5.222)
 Center 1.031 (0.979, 1.085) 1.927 (1.790, 2.075)
 East 0.973 (0.942, 1.005) 1.835 (1.746, 1.929)
COPD
 US 0.987 (0.957, 1.019) 1.582 (1.491, 1.679)
 West 0.928 (0.878, 0.981) 3.373 (2.878, 3.952)
 Center 1.018 (0.950, 1.090) 1.558 (1.409, 1.723)
 East 1.020 (0.972, 1.070) 1.131 (1.053, 1.216)
Pneumonia
 US 0.960 (0.922, 0.999) 6.867 (6.161, 7.413)
 West 0.953 (0.893, 1.017) 10.081 (8.312, 12.225)
 Center 1.084 (0.973, 1.207) 3.807 (3.281, 4.417)
 East 0.914 (0.861, 0.970) 3.933 (3.592, 4.306)
All cancer
 US 1.019 (1.003, 1.035) 1.596 (1.551, 1.642)
 West 1.002 (0.973, 1.032) 1.412 (1.300, 1.534)
 Center 1.044 (1.006, 1.083) 1.415 (1.343, 1.491)
 East 0.999 (0.978, 1.021) 1.444 (1.397, 1.493)
Lung cancer
 US 1.033 (1.002, 1.064) 1.535 (1.451, 1.623)
 West 1.003 (0.946, 1.063) 1.614 (1.371, 1.902)
 Center 1.089 (1.014, 1.170) 1.426 (1.291, 1.575)
 East 1.017 (0.975, 1.061) 1.330 (1.247, 1.418)
a

Age, gender, and race-stratified and state-adjusted Poisson regression models; additionally adjusted for PM2.5 using two-stage models.