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KO of Stxbp1 in the primary L-cell impairs GLP-1 secretion ex vivo. GLP-1 secretion assay in primary adult mouse ileal crypt cultures from L-cell Stxbp1 KO and control mice. Cells were treated for 2 hours with 50 µM forskolin (F) plus 50 µM IBMX (I) or vehicle alone (control). (A) Percent GLP-1 secretion and (B) total cell content of GLP-1. (n = 6–7). *P < 0.05, ***P < 0.001. CON, control; IBMX, 3-isobutyl-1-methylxanthine; KO, knockout.
