Table 6.
Disease enrichment analysis of chameleon sequences in seven residues in length.
| Gene-set library | Type of chameleons |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Type of disease | |||||||||||
| Neurodegenerative diseasea | Blood disorder | Colorectal cancer | Eye disorderb | Mental disorderc | Lung disease | Liver disease | Artritis | IBDd | Type 2 diabetes mellitus | CFe | |
| HE-Chameleons | |||||||||||
| OMIM | √ | √ | – | – | – | – | – | – | – | – | – |
| Disease Perturbations from GEO UP | √ | – | √ | √ | √ | √ | – | √ | √ | – | – |
| Disease Perturbations from GEO Down | √ | – | – | – | √ | – | – | – | – | – | – |
| HC-Chameleons | |||||||||||
| OMIM | – | √ | √ | – | – | – | – | – | – | – | – |
| Disease Perturbations from GEO UP | – | √ | – | – | – | √ | √ | √ | √ | – | – |
| Disease Perturbations from GEO Down | √ | √ | – | – | – | – | – | – | – | √ | √ |
| CE-Chameleons | |||||||||||
| OMIM | – | – | – | – | – | – | – | – | – | – | – |
| Disease Perturbations from GEO UP | – | – | – | – | – | – | √ | – | √ | – | – |
| Disease Perturbations from GEO Down | – | – | – | – | – | – | – | – | – | – | √ |
a
Neurodegenerative disease including Parkinson's disease, Alzheimer's disease, Huntington's disease, Amyotrophic lateral sclerosis (ALS), Alexander disease.
b
Eye disease including Leber congenital amaurosis and Retinoschisis.
c
Mental disorders including schizophrenia, bipolar disorder, Anxiety disorders.
d
IBD, inflammatory bowel disease.
e
CF, cystic fibrosis.