Table 5.
Protective effect of BMAP-27 and -28 against E. coli, P. aeruginosa and S. aureus in an acute peritonitis mouse model
| Mouse group receiving |
E. coli O18:K1:H7 |
P. aeruginosa ATCC 27853 |
S. aureus (MRSA) |
|||||||||
| Survivala | Pb | Survivala | Pb | Survivala | Pc | |||||||
| No infection | 10/10 | 10/10 | 10/10 | |||||||||
| No peptide | 0/10 | 0/10 | 0/10 | |||||||||
| BMAP-27 (mg/kg) | ||||||||||||
| 0.2c | 10/10 | <0.0001 | – | – | ||||||||
| 0.4 | 10/10 | <0.0001 | 8/10 | 0.0007 | – | |||||||
| 0.8 | – | 10/10 | <0.0001 | – | ||||||||
| 1.6 | – | – | 3/10 | nsd | ||||||||
| 3.2 | – | – | 2/10 | ns | ||||||||
| 6.4 | – | – | 2/10 | ns | ||||||||
| BMAP-28 (mg/kg) | ||||||||||||
| 0.2 | – | – | 5/10 | 0.0325 | ||||||||
| 0.4 | 2/10 | ns | 1/10 | ns | 8/10 | 0.0007 | ||||||
| 0.8 | 8/10 | 0.0007 | 3/10 | ns | 10/10 | <0.0001 | ||||||
| 1.6 | 10/10 | <0.0001 | 8/10 | 0.0007 | – | |||||||
a
Number of mice surviving/total number.
b
By Fisher’s exact test.
c
Dose of peptide administered i.p. in a single injection after intraperitoneal bacterial challenge.
d
Not significant.