Table 2.
Chitosan, M-chitosan and MBCO microspheres encapsuled PEI/DNA within it
| Formulation | Mean size (nm)a | Encapsulation efficiency (%) | Zeta potential (mV)b |
|---|---|---|---|
| Chitosan | 415.2±44.2 | (94±5.4) | 19.44±2.78 |
| M-chitosan | 326.3±31.9 | (89±2.6) | 10.19±3.23 |
| MBCO | 246.9±30.8 | (82.5±3.4) | 4.12±0.64 |
| PEI/DNA (N/P=6) | 86.6±30.2 | 36.64±1.77 |
a
The mean size of microspheres was measured by DLS.
b
The zeta potentials of chitosan derivatives microspheres was measured at pH 5.5 and PEI/DNA complexes were measured at pH 7.2. All data were expressed as mean±SD (n=3).