Table 2.

Odds ratios (95% confidence intervals) and P-value of the unadjusted and adjusted metabolite measurements (a) at 12, 20 and 28 wkGA in relation to pre-term pre-eclampsia (n = 29) and (b) at 36 wkGA in relation to term pre-eclampsia (n = 165) in the case–cohort sample (total n = 504)

		Odds ratios (95% confidence intervals) and P-value
Metabolite	Model	12 wkGA and pre-term PE	20 wkGA and pre-term PE	28 wkGA and pre-term PE	36 wkGA and term PE
4-hydroxyglutamate	Unadjusted	2.04 (1.37 to 3.04)	2.38 (1.46 to 3.88)	2.37 (1.53 to 3.66)	2.24 (1.70 to 2.96)
		P=0.0004	P=0.0005	P=0.0001	P<0.0001
	Adjusted	1.99 (1.33 to 2.98)	2.40 (1.45 to 3.98)	2.05 (1.29 to 3.26)	1.87 (1.42 to 2.47)
		P=0.0009	P=0.0007	P=0.0024	P<0.0001
C-glycosyltryptophan	Unadjusted	1.48 (0.97 to 2.24)	1.58 (1.08 to 2.33)	2.26 (1.48 to 3.45)	2.67 (2.05 to 3.48)
		P=0.067	P=0.020	P=0.0001	P<0.0001
	Adjusted	1.37 (0.88 to 2.13)	1.56 (1.05 to 2.33)	1.98 (1.27 to 3.10)	2.55 (1.92 to 3.38)
		P=0.17	P=0.029	P=0.0027	P<0.0001

Odds ratios are given for 1 standard deviation increase in the log-transformed metabolite. Adjusted models are only adjusted for the other metabolite. All P-values are two-sided. wkGA, weeks of gestational age; PE, pre-eclampsia.