Table 1.
Clinical and Demographic Variables according to the Presence of Severe AKI on Day 3 of Septic Shock
| Variable | No Severe D3 SA-AKI | Severe D3 SA-AKI | P Value |
|---|---|---|---|
| n (%) | 314 (83) | 65 (17) | — |
| Age, yr* | 6.5 (2.5–12.4) | 5.1 (1.3–13.5) | 0.32 |
| Sex, M, n (%) | 162 (52) | 33 (51) | 0.99 |
| PRISM III* | 10 (6–14) | 14 (10–20.5) | <0.001 |
| PERSEVERE II mortality risk* | 0.007 (0.007–0.167) | 0.189 (0.019–0.33) | <0.001 |
| Organism, n (%) | |||
| Gram positive | 68 (22) | 13 (20) | 0.90 |
| Gram negative | 77 (25) | 19 (29) | 0.52 |
| Viral | 23 (7) | 6 (9) | 0.79 |
| Fungal | 6 (2) | 4 (6) | 0.13 |
| None | 140 (45) | 23 (35) | 0.22 |
| Mortality, n (%) | 18 (6) | 24 (37) | <0.001 |
| PICU LOS, d* | 6 (3–12) | 10 (7–21) | <0.001 |
| PICU-free days* | 22 (14–25) | 5 (0–19) | <0.001 |
Definition of abbreviations: D3 SA-AKI = sepsis-associated acute kidney injury on Day 3; LOS = length of stay; PERSEVERE-II = updated Pediatric Sepsis Biomarker Risk Model; PICU = pediatric ICU; PRISM III = Pediatric Risk of Mortality score.
*
Continuous variables are reported as median (interquartile range).