Table 2.
Multivariable Logistic Regression Testing for an Association between PERSEVERE-II Mortality Probability and Septic Shock–associated Acute Kidney Injury Outcomes
| Outcome | Variable | n | Odds Ratio | 95% CI | P Value |
|---|---|---|---|---|---|
| Severe D3 SA-AKI | PERSEVERE-II* | 379 | 1.4 | 1.2–1.7 | <0.001 |
| PRISM III | 1.1 | 1.0–1.1 | <0.001 | ||
| Age (yr) | 1.0 | 0.9–1.0 | 0.972 | ||
| RRT use | PERSEVERE-II* | 379 | 1.6 | 1.3–2.0 | <0.001 |
| PRISM III | 1.1 | 1.0–1.1 | 0.003 | ||
| Age (yr) | 1.0 | 1.0–1.1 | 0.581 | ||
| Day 3 renal recovery | PERSEVERE-II* | 131 | 1.3† | 1.0–1.6 | 0.047 |
| PRISM III | 1.0 | 0.9–1.1 | 0.745 | ||
| Age (yr) | 1.0 | 0.9–1.1 | 0.962 |
Definition of abbreviations: CI = confidence interval; D3 SA-AKI = sepsis-associated acute kidney injury on Day 3; PERSEVERE-II = updated Pediatric Sepsis Biomarker Risk Model; PRISM III = Pediatric Risk of Mortality score; RRT = renal replacement therapy.
*
The raw PERSEVERE-II mortality probability was transformed by a factor of 10 for the logistic regression analyses.
†
Lower PERSEVERE-II mortality probability associated with increased odds of renal recovery.