Table 2.
Categories of silkworm PTPs.
| PTP subfamily/Gene ID | Signature motif | Characteristic domain | Human ortholog | Fruitfly ortholog | Sequence source | |
|---|---|---|---|---|---|---|
| Classical pTyr-specific PTPs | ||||||
| Receptor | 101746939 | VHCSAGVGRT VHCQTGCERS |
IG, FN3 | RPTPα | PTP69D | EST,CDS |
| 101736187 | VHCSAGVGRS | FN3 | RPTPβ | PTP10D | FL cDNA | |
| 101737535 | VTCASGAGRS | PTPRγ | CG42327 | FL cDNA | ||
| 101738718 | VHCSDGAGRS | RPTPN2 | RPTPN2 | IA-2 | FL cDNA | |
| 101736712 | IHCSAGIGRT | PTPRR | PTP-ER | FL cDNA | ||
| 101747207 | VHCSAGVGRT | PTPRS | PTP99A | CDS | ||
| Non-receptor | 100579140 | VHCSAGIGRS | PTP1B | PTP61F | FL cDNA | |
| 101737573 | VHCSAGVVRT | ERM,FERM_C,PDZ | PTPN4 | PTPmeg | EST,CDS | |
| 101744807 | VHCSAGIGRT | CRAL_TRIO_N,Sec14 | PTPN9 | l(1)G0232 | FL cDNA | |
| 101735618 | YCCGEGAGRS | ERM,FERM_C | PTPN14 | Pez | CDS | |
| 101736631 | IQCGAGAGRS | BRO1-like | PTPN23 | MOP | EST,CDS | |
| 101736863 | VHCSAGVGRT | SH2 | SHP2 | Csw | EST,CDS | |
| 101737822 | VHCSAGIGRT | SH2 | SHP2 | Csw | CDS | |
| 101735492 | VHCNDGGGRS VHCNDGGGRS | RPTPκ | PTP36E | EST,CDS | ||
| VH1-like dual-specificity PTPs | ||||||
| MKP | 101744546 | VHCHFGVSRS | MKP-4 | MKP-4 | FL cDNA | |
| 101740325 | VHCVAGVSRS | DUSP7 | MKP-3 | EST,CDS | ||
| PTEN | 101745952 | VHCKAGKGRT | PTEN_C2 | PTEN | PTEN | EST,CDS |
| PRL | 101743511 | VHCVAGLGRA | PRL-1 | PRL-1 | FL cDNA | |
| Slingshot | 101737293 | VHCKMGISRS | SSH-N, DEK_C | SSH1 | SSH | FL cDNA |
| CDC14 | 101740096 | VHCKAGLGRT | CDC14A | CDC14 | EST,CDS | |
| 101744892 | IHCHAGLGRT | PTP9Q22 | CDC14 | EST,CDS | ||
| Myotubularin | 101740354 | VHCSDGWDRT | FYVE | MTMR3 | CG3632 | EST,CDS |
| 101736509 | VHCSDGWDRT | FYVE | MTMR6 | CG3530 | FL cDNA | |
| 101739438 | FLCDTDQERQ | MTMR9a | CG5026 | EST,CDS | ||
| 101736147 | VHCSDGWDRT | GRAM | MTMR2 | MTM | FL cDNA | |
| Atypical | 692515 | VHCTHGLNRT | DUSP11 | CG13197 | FL cDNA | |
| 101738891 | VHCYFGVSRS | DUSP12 | MKP-4 | FL cDNA | ||
| 101738231 | VHCMIGVSRS | DUSP13 | CG7378 | FL cDNA | ||
| 101743164 | VHCVAGVSRS | DUSP14 | CG15528 | EST,CDS | ||
| 101735761 | IHCLAGMSRS | DUSP22 | CG10089 | FL cDNA | ||
| 101744063 | IHCRQGRSRS | DUSP23b | CDC14b | FL cDNA | ||
| 101742480 | VHCRHGRGRT | DUSP23b | CDC14b | EST,CDS | ||
| 101737334 | VHCKAGRTRS | PTPMT1 | Plip | FL cDNA | ||
| 101740551 | VHCTHGFNRT | NADH_4Fe–4S | mRNA-cap | mRNA-cap | FL cDNA | |
| Low molecular weight PTP | ||||||
| 692857 | FICLGNICRS | LMWP | Primo-1 | FL cDNA | ||
| CDC25 | ||||||
| 100216491 | FHCEFSLERG | RHOD | CDC25C | Stg | EST,CDS | |
Information of BmPTP-h is highlighted in bold.
a
Human MTMR9 has been proved to be a catalytic inactive phosphatase.
b
No clear orthology relationship could be ascribed to two silkworm atypical PTPs (101744063, 101742480).