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. Author manuscript; available in PMC: 2020 Apr 4.
Published in final edited form as: Psychopharmacology (Berl). 2020 Jan 7;237(4):1209–1221. doi: 10.1007/s00213-019-05450-6

Figure 5. Paternal morphine self-administration impairs long-term object recognition memory in female but not male progeny.

Figure 5.

A. Saline-sired (n=14, from 9 sires) and morphine-sired male rats (n=14, from 8 sires) both show a preference for the novel object during the 24-hour object recognition memory test compared to their initial preference during the training trial. (* p<0.05) B. Saline-sired female rats (n = 14, from 9 sires) spent equal time exploring both objects during training, and showed a preference for the novel object during a test 24-hours after training. In contrast, morphine-sired female rats (n = 13, from 9 sires) spent equal time exploring both objects during training and during the 24-hour memory test. (*p<0.01 comparing training preference to preference during 24-hour test using Bonferroni post-hoc correction).