Table 2. Summary of differential methylation patterns.

Following data extraction, normalization and peak selection, differentially methylated regions (DMRs) were identified by pattern generation and filtering. Each identified peak was classified into 5 patterns wherein the control, folic acid, and folic acid + TSA replicates are shown in the 13, 4–6, and 7–9 components of the pattern, respectively. The table classifies the DMRs with respect to CpG island and gene promoters.

Pattern	0.0.0.1.1.1.0.0.0	0.0.0.1.1.1.1.1.1	1.1.1.0.0.0.0.0.0	1.1.1.0.0.0.1.1.1	1.1.1.1.1.1.0.0.0
Number of DMRs	229	289	278	112	972
Number of DMRs mapping to gene promoters	180	237	210	96	828
Number of genes with DMR	89	72	149	30	306
Number of genes with a highly significant DMR	52	49	81	8	216
Number of unique genes with a DMR in a CpG Island	34	40	9	17	88
Number of DMRs in non-genes CpG Islands	22	12	10	9	70