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. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2020 Feb 12;29(4):860–870. doi: 10.1158/1055-9965.EPI-19-0891

Table 3.

Additive interaction between genetically-predicted polyunsaturated fatty acid (PUFA) intake and regular aspirin/NSAID use in the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO)

Polyunsaturated fatty acid levelsa Aspirin/NSAID use Cases / Controls ORb 95% CI p RERIc 95% CId
Linoleic acid (LA)
 Low No 3,590 / 3,722 1.00
 High No 3,329 / 3,950 0.89 0.84–0.95 7.8×10−4
 Low Yes 1,545 / 2,505 0.71 0.65–0.77 3.3×10−17
 High Yes 1,513 / 2,559 0.68 0.63–0.74 2.0×10−20 0.083 −0.004 – 0.170
Arachidonic acid (AA)
 Low No 3,321 / 4,002 1.00
 High No 3,598 / 3,670 1.15 1.07–1.23 4.4×10−5
 Low Yes 1,505 / 2,619 0.76 0.70–0.82 8.4×10−12
 High Yes 1,553 / 2,442 0.82 0.76–0.89 1.9×10−6 −0.082 −0.185 – 0.021
α-linolenic acid (ALA)
 Low No 3,603 / 3,667 1.00
 High No 3,316 / 4,005 0.87 0.81–0.93 4.1×10−5
 Low Yes 1,566 / 2,437 0.72 0.67–0.78 2.4×10−15
 High Yes 1,492 / 2,624 0.65 0.60–0.71 3.2×10−25 0.059 −0.028 – 0.146
Eicosapentaenoic acid (EPA)
 Low No 4,046 / 4,476 1.00
 High No 2,873 / 3,196 1.12 1.05–1.20 7.6×10−4
 Low Yes 1,807 / 3,111 0.76 0.70–0.82 1.9×10−11
 High Yes 1,251 / 1,950 0.80 0.74–0.87 4.4×10−8 −0.081 −0.182 – 0.021
Docosapentaenoic acid (DPA)
 Low No 3,848 / 4,105 1.00
 High No 3,071 / 3,567 1.07 1.00–1.15 3.9×10−2
 Low Yes 1,665 / 2,706 0.76 0.70–0.82 8.2×10−12
 High Yes 1,393 / 2,355 0.77 0.71–0.83 8.1×10−11 −0.063 −0.161 – 0.035
Docosahexaenoic acid (DHA)
 Low No 4,052 / 4,627 1.00
 High No 2,867 / 3,045 1.05 0.98–1.13 0.13
 Low Yes 1,806 / 3,140 0.72 0.67–0.78 5.1×10−18
 High Yes 1,252 / 1,921 0.80 0.73–0.87 2.5×10−7 0.024 −0.075 – 0.124
a

Genetically-predicted polyunsaturated fatty acid intake dichotomized at the median (i.e., wGS < median = “Low” and wGS ≥ median = “High”).

b

All models adjusted for age, sex, study, and top principal components for European ancestry.

c

Additive interaction assessed using the Relative Excess Risk due to Interaction (RERI) = OR11 – OR10 – OR01 + 1 (e.g., Linoleic acid RERI = 0.68 – 0.71 – 0.89 + 1 = 0.08).

d

95% CI for RERI estimated using method of Hosmer & Lemeshow.[26]