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Antiproliferative activities of 1–3 on MV4–11 AML and NB4 APL cell lines.
| Compd | Metabolic stability data[a] | |
|---|---|---|
| Mouse Clint (μL/min/mg protein) | Human Clint (μL/min/mg protein) | |
| 3a | 7.1 ± 2.2 | 6.7 ± 1.1 |
| 3d | 4.3 ± 0.7 | 12.2 ± 1.7 |
| 3g | 11.2 ± 1.8 | lower than 3 |
Data are expressed as the mean of at least two determinations ± standard deviation.
