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. Author manuscript; available in PMC: 2021 Apr 1.
Published in final edited form as: Mol Neurobiol. 2019 Dec 14;57(4):1781–1798. doi: 10.1007/s12035-019-01838-9

Fig 1.

Fig 1

Experimental design. Two animal cohorts were used: cohort 1 were females (10 WT, 10 PINK1-KO) and males (10 WT, 10 PINK1-KO), distributed in four conditions (WT S-, WT S+, PINK1-KO S-, PINK1-KO S+) of 5 animals per group. Cohort 2 were males (8 WT, 10 PINK1-KO). Cohort 1 (for the study of acute effect of stress) was stressed for three days and the tissue collection was made on the third day. Cohort 2 (for the study of long-term effect of stress) was trained and tested for behavior and motor function, then stressed for three days (day1-day3), tested again for behavior and motor function in day 4, rest for 7 days, and finally tested for the third time for behavior and motor function and tissue collected in day 10. A: Training for rotarod test and beam balance test; B: Testing for rotarod test, grip strength test, beam balance test and cat-odor avoidance test; S: Sacrifice, tissue collection, Seahorse XF24 metabolic assay.