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. Author manuscript; available in PMC: 2020 May 1.
Published in final edited form as: Mod Pathol. 2019 Nov 1;33(4):648–656. doi: 10.1038/s41379-019-0398-2

Figure 5:

Figure 5:

Schematic representations of PRKACA fusions detected by the MSK-Fusion targeted RNASeq assay. A. DNAJB1-PRKACA in-frame fusion resulting from a 400 Kb deletion on chromosome 19 and joining exon1 of DNAJB1 (NM_006145) to exons 2-10 of PRKACA (NM_002730). B. ATP1B1-PRKACA fusion derived from a translocation between chromosome 1 and chromosome 19. This in-frame fusion event involves exon 1 of ATP1B1 (NM_001677) and exons 2-10 of PRKACA (NM_002730). The chimeric transcript sequence and its corresponding protein sequence are indicated under the fusion breakpoint region. +/− indicate the direction of transcription of each gene.