Table 1:

Clinicopathologic Features of the Pancreatobiliary Neoplasms with PRKACA Fusions

Case	Age/Sex	Initial Presentation	Pathology Diagnosis			Clinical Follow-up
			Intraductal Component	Invasive Component	Metastasis
1	63/M	7 cm mass in head of the pancreas	IOPN	Invasive adenocarcinoma with mucinous and oncocytic features	Not applicable	No follow up data available
2	47/M	10 cm cystic mass in caudate lobe of liver	IOPN of the bile ducts	Invasive adenocarcinoma with oncocytic features	Not applicable	Recurrence after 4 years; now deceased
3	36/M	4.5 cm cystic mass in head of the pancreas	IOPN	Not applicable	Not applicable	No evidence of disease for 10 years
4	58/F	Complex cystic mass in head of the pancreas	IPMN, mixed oncocytic and pancreatobiliary features	Minute focus of invasion with mucinous and oncocytic features	Not applicable	No adjuvant therapy given. No evidence of disease for 9 months
5	52/M	2.8 cm cystic mass in head of the pancreas	IPMN, mixed oncocytic and gastric features	Not applicable	Not applicable	No evidence of disease for 6 years
6	76/M	Distal pancreatic mass	IPMN, mixed oncocytic and pancreatobiliary features	Invasive adenocarcinoma	Metastatic adenocarcinoma with oncocytic features, involving liver	Recurrence and liver metastases after 20 years, disease progression despite chemotherapy

IOPN: Intraductal oncocytic papillary neoplasm; IPMN: Intraductal papillary mucinous neoplasm