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. 2020 Apr 3;11:1663. doi: 10.1038/s41467-020-15540-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Heatmap of rates for all measured single and double mutants, with the first constituent point mutation indicated on the ordinate and the second on the abscissa. Sequence regions participating in duplex structures are labeled and color-coded as in Fig. 1. Heatmap of cleavage rates of all single mutants and basepaired-partner double mutants superimposed on the ribozyme tertiary (b) and secondary (c) structure, with secondary elements indicated in the same color scheme as a. The structure in b is based on PDB 2Z75. Source data are available in the Source Data file.