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. 2020 Apr 3;10:5852. doi: 10.1038/s41598-020-62615-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of Na_VSp1 S4-S5_L mimicking peptides on Na_VSp1 current density and activation curve. (A) representative, superimposed current recordings in COS-7 cells transfected with Na_VSp1 and control 1 (top trace) or S4-S5_L(−3) peptide (bottom trace). Inset: activation voltage protocol used (holding potential: −90 mV; 300-ms pulse at the indicated potentials; one sweep every 5 s). (B) Dot plot and mean ± sem of peak Na_VSp1 current densities recorded in COS-7 cells co-transfected with Na_VSp1 and the indicated peptide, at 30 mV. (C) Relative peak conductance versus membrane potential curves for Na_VSp1 channels in COS-7 cells co-transfected with Na_VSp1 and the indicated peptide. Lines are Boltzmann fits to the data. (D,E) Dot plot and mean ± sem of Na_VSp1 half-activation potential (V_0.5; D) and activation slope (K; E) in COS-7 cells co-transfected with Na_VSp1 and the indicated peptide. *p value vs. both controls <0.05.