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. 2020 Apr 3;10:5852. doi: 10.1038/s41598-020-62615-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of charge reversal in amino acids present in Na_VSp1 S4-S5_L(−3) activating peptide on Na_VSp1 current density and activation curve. (A) representative, superimposed recordings of WT and mutant Na_VSp1 current. Activation voltage protocol used is the same as in Fig. 2. (B–D) Dot plot and mean ± sem of peak current densities recorded in COS-7 cells transfected with WT or mutant Na_VSp1, at 30 mV. (E) Relative peak conductance versus membrane potential curves for WT or mutant Na_VSp1 channels transfected in COS-7. Lines are Boltzmann fits to the data. ***p value vs. WT < 0.001.