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. 2020 Apr 3;10:5852. doi: 10.1038/s41598-020-62615-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect on Na_V1.4 channel expression of S4-S5_L mimicking peptides associated with an increased current density. Left: (A,C) representative western blots of total Na_V1.4, transferrin receptor (TransR) and GAPDH from transfected COS-7 cells, in the presence of various control and S4-S5_L peptides as indicated. (B,D) representative western blots of the cell surface fraction of Na_V1.4, transferrin receptor (TransR) and GAPDH from transfected COS-7 cells, in the presence of various control and S4-S5_L peptides. Right: corresponding quantifications of normalized mean ± sem intensities. Band intensities are first normalized to the intensity of the corresponding TransR bands, and ratios are then normalized to control 1 condition. In all condition, p > 0.05. In A–D, the three blots, realized on the same membrane, are cropped. Full-length blots of each tested protein are reported in Supplemental Fig. 5.