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. 2020 Apr 3;10:5874. doi: 10.1038/s41598-020-62543-5

Figure 2.

Figure 2

CFA-dependent cell-mediated immune responses as a function of host Nod2 and Mincle. Proportion of cytokine-producing CD4+CD8- lymph node cells of mice immunized against OVA with CFA or IFA seven days prior. (A,B) Nod2+/+ vs. Nod2−/− mice, data representative of two independent experiments with averages +/−SEM. p-values were calculated with two-tailed student’s t-tests. *p < 0.05; **p < 0.01. For CFA Nod2+/+, CFA Nod2−/−, IFA Nod2+/+ and IFA Nod2−/−, sample size N = 12, 13, 9 and 7 mice, respectively. (C,D), Mincle+/+ vs. Mincle−/− mice, data pooled from two independent experiments with averages +/- SEM. p-values were calculated with two-tailed student’s t-tests. *p < 0.05; **p < 0.01. For CFA Mincle+/+, CFA Mincle−/−, IFA Mincle+/+ and IFA Mincle−/−, sample size N = 14, 16, 15 and 11 mice, respectively. (E,F) WT (Mincle+/+Nod2+/+) vs. DKO (Mincle−/−Nod2−/−) mice with averages +/- SEM. p-values were calculated with two-tailed student’s t-tests. *p < 0.05; **p < 0.01. For CFA WT, CFA DKO, IFA WT and IFA DKO, sample size N = 10, 7, 7 and 7 mice, respectively.