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. 2020 Apr 3;10:5874. doi: 10.1038/s41598-020-62543-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Dynamics of cDCs in lymph nodes after immunization with synthetic mycobacterial MAMPs. (A) CD11b+ cDC quantities and median fluorescence intensity of MHC-I, MHC-II, CD40, CD80 and CD86 in mice immunized with the indicated adjuvants after 4 or 7 days. (B) CD11b- cDC quantities and median fluorescence intensity of MHC-I, MHC-II, CD40, CD80 and CD86 in mice immunized with the indicated adjuvants after 4 or 7 days. For all adjuvant groups, N = 8 mice, except for IFA+MDP at 7 days p.i. where N = 4 (each plotted point represents data from an individual mouse). Shown are averages +/− SEM. To determine if IFA + GlcC14C18 + N-glycolyl MDP altered cDC parameters compared to IFA alone, p-values were calculated using Dunnett’s T3 multiple comparisons test correcting for multiple timepoints and cDC type (CD11b+/−). *p < 0.05; **p < 0.01; ns, not significant, p > 0.05.