Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Apr 3;10:5874. doi: 10.1038/s41598-020-62543-5

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Spinal cord pathology in RR-EAE mice induced by IFA+GlcC14C18+MDP. (A) Nissl and Luxol fast blue (LFB) stains of spinal cord sections from RR-EAE-induced mice at day 28 post injection, having an EAE score of 3.5 upon euthanasia. Red boxes highlight cellular infiltration and spatially associated demyelination of the white matter seen by Nissl and LFB staining, respectively. (B) Quantitative spinal cord pathology per EAE score upon euthanasia. Statistical significance was determined by Tukey’s multiple comparisons test. *p < 0.05 and ****p < 0.0001. N = 40 sections for each group (20 from CFA and 20 from synthetic adjuvant of equivalent EAE scores). Lines indicate averages +/− SEM (C), Quantitative spinal cord pathology per adjuvant. Statistical significance was tested with two-tailed unpaired Welch’s t-test; a power calculation for given variances and N = 60 sections per group indicated an ability to discern +/− 15% difference vs. CFA control. Lines indicate averages +/− SEM.