Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Apr 3;10:5859. doi: 10.1038/s41598-020-62755-9

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

The anti-apoptotic and anti-inflammatory effects of Si-based agent on renal function. (a) Interstitial phenotypic changes are assessed by immunohistochemical staining of α-SMA (arrow) in the control group (i) or the Si-based agent (0.1wt.%-1.0wt.%) groups (ii-iv). The positive area was quantitatively assessed using a color image analyzer (v). (b) TUNEL method was performed for measuring the levels of apoptosis in each group as describe above (i-iv). We counted the number of TUNEL-positive cells (arrow) per 100 cells in ten random areas of each rats (v). Scale bar: 100 µm. (c-f) The normalized messenger RNA (mRNA) level of caspase-3 (c), C-C motif chemokine ligand 2 (CCL2) (d), interleukin-6 (IL-6) (e), and a tissue inhibitor of metalloproteinases (TIMP-1, f) were measured. The levels are normalized to β-actin levels for each sample. The y-axis values represent the number of copies relative the number of copies in the same samples. The levels are normalized to β-actin levels for each sample. The y-axis values represent the number of copies relative the number of copies in the same samples. Data were expressed as mean +/− SD. **p < 0.01, *p < 0.05 vs. the control group, respectively.