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. 2020 Apr 3;6:8. doi: 10.1038/s41540-020-0125-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Design 4, Design 5, and Design 6 describe known inhibitory regulations mediated by Clb/Cdk1 activities. b Design 7, Design 8, and Design 9 describe hypothetical inhibitory regulations mediated by Sic1. Colored lines indicate new regulations, with each color identifying a particular network design. Dashed lines indicate regulations occurring in two different designs. In the latter, the two designs related to each such interaction are shown with the same color. Black lines indicate the activatory and inhibitory regulations occurring in the minimal cell cycle model. See text and Supplementary Information, Section 3 for details about the specific molecular mechanisms.