Table 2.
Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis for differentially expressed genes between activated intra-melanoma DP and CD4 SP T cells.
| Gene Expression Data Set | NG | P-value | FDR | Genes |
|---|---|---|---|---|
| KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION | 13 | 1.1E-6 | 2.1E-4 | IL4, CSF2RA, IL8, IL6R, OSM, IL21, IL21R, XCL1, TNFRSF13C, TNFSF4, TNFRSF4, TNFSF14, TNFRSF18 |
| KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY | 8 | 6.5E-6 | 4.1E-4 | IL4, NFKB1, MAP3K14, PPP3CA, NFAT5, CD8a, CD8b, CD247 |
| KEGG_MAPK_SIGNALING_PATHWAY | 12 | 6.6E-6 | 4.1E-4 | NFKB1, MAP3K14, PPP3CA, MYC, FGFR3, FGF4, PRKX, RPS6KA3, NTRK2, GADD45B, DUSP4, NR4A1 |
| KEGG_JAK_STAT_SIGNALING_PATHWAY | 9 | 1.3E-5 | 4.7E-4 | IL4, CSF2RA, IL6R, OSM, IL21R, IL21, MYC, BCL2L1, SPRY1 |
| KEGG_APOPTOSIS | 7 | 1.5E-5 | 4.8E-4 | NFKB1, MAP3K14, PPP3CA, PRKX, BCL2L1, BIRC3, CASP7 |
| KEGG_CHEMOKINE_SIGNALING_PATHWAY | 8 | 3.5E-4 | 8.2E-3 | IL8, XCL1, NFKB1, PRKX, ADCY1, PRKCD, SHC4, ELMO1 |
| KEGG_WNT_SIGNALING_PATHWAY | 7 | 4.6E-4 | 9.6E-3 | PPP3C4, NFAT5, MYC, PRKX, DVL1, FZS3, AXIN2 |
NG: number of Genes, FDR: False Discovery Rate.