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. 2020 Apr 3;11:1674. doi: 10.1038/s41467-020-15412-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Schematic: Neocortical IUE at E13 (left) with CAG-GFP and either Ctrl or Elavl4 constructs were analyzed at E17 for colocalization between GFP and neocortical layer markers as indicated in the chart on the right. Nctx = neocortex, UL = upper layers, LL = lower layers, IC = intracortically projecting. b Representative mages of E17 IUE Nctx, corpus callosum, and striatum. GFP+ axons (green) are indicated by arrowheads. Scale bar: 200 μm. c Representative images of immunostained E17 IUE Nctx electroporated with GFP and either Ctrl (n = 3 animals), Nestin:Elavl4-v3 (n = 4 animals), or Nestin:Elavl4-v4 (n = 4 animals) OE. IHC for GFP (green) and cortical neuron identity markers (red) listed in a. Scale bar: 20 μm. d Quantification of colocalization between layer markers and GFP, normalized to Ctrl. Data represent the mean of sections and SEM. Statistics: one-way ANOVA with Tukey’s. *p < 0.05, **p < 0.01, ***p < 0.001.