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. 2020 Apr 3;11:1680. doi: 10.1038/s41467-020-15332-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Heatmap of differentially expressed genes between control (Ctrl) and βCat-GOF adrenals based on normalized counts. Fold change > 1.4, adjusted P value < 0.05, base mean expression > 100 were used as cut-off criteria. Dendrograms represent hierarchical clustering of samples (top, Spearman correlation) and genes (left, Pearson correlation) using the average linkage method. N = 6, 6 female mice. b Gene Ontology terms (Biological Processes) enriched in βCat-GOF adrenals. c Western blots showing increased FGFR2 in βCat-GOF adrenals compared to Ctrl. d Normalized luminescence intensity of (c). Student’s t test, **P < 0.01, N = 5, 5 female mice. e Single-molecule in situ hybridization (RNAscope) of Fgfr2 and Shroom3 in Ctrl and βCat-GOF female adrenals. Blue, hematoxylin counterstain. Dotted line demarcates zG/zF boundary; boxed areas are shown at higher magnification on the right. c capsule, zG zona glomerulosa, zF zona fasciculata. Bars, 10 μm. In all bar plots, error bars represent SEM. Source data are provided as a Source Data file.